Thematic leaders: Hang Nguyen and Jérémy Denizot

  • Impact of AIEC colonization on chronic intestinal inflammation in a susceptible host.
    • Influence of host susceptibility factors (e.g., autophagy, epigenetics) on intestinal homeostasis, gut microbiota and susceptibility to AIEC infection and subsequent gut inflammation.
    • Impact of AIEC on epithelial physiology (Epigenetic modifications in intestinal epithelial cells; Exosomes in cell-to-cell communication and host response to AIEC infection).
    • Modulation of the mucosal immune homeostasis by AIEC bacteria.
    • Impact of environmental factors on host-AIEC interaction.
  • Impact of environmental factors and chronic pathobiont colonization on colorectal carcinogenesis.
    • The impact of cyclomodulin-producing E. coli (CPEC) on colorectal carcinogenesis.
    • Impact of CPEC infection on epithelial cell compartment (Involvement of oxidative stress in the pro-carcinogenic effect of CPEC; Role of CPEC in the emergence of cancer chemotherapy resistance and epithelial to mesenchymal transition).
    • Interaction of chronic CPEC infection with host immune system (Innate immune response with a focus on autophagy; Impact of CPEC chronic infection on anti-tumor immune response with a focus on T cells).
    • Impact of microsporidiosis on the occurrence of colorectal cancer.
    • Impact of xenobiotics on CPEC colonization and colorectal carcinogenesis.